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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Neuropharmacology. 2016 Nov 19;114:20–33. doi: 10.1016/j.neuropharm.2016.11.013

Table 2.

Mean open times in GluN2A(F636/F637) mutants

Substituents at GluN2A(F636/F637) Mean Open Time (ms) N
WT (F/F) 3.4 ± 0.21 22
A/F 3.1 ± 0.42 5
F/A 0.82 ± 0.084*** 6
A/A 0.77 ± 0.034 *** 5
I/I 1.4 ± 0.25** 5
W/F 14 ± 1.6*** 10
F/W 0.51 ± 0.055*** 9
W/W 3.2 ± 0.36 6
A/W 0.81 ± 0.080*** 5
W/A 3.2 ± 0.47 6

WT(F/F), wild-type. Values are the means ± S.E. obtained from 5 to 22 patches. Significant differences from values obtained for the wild-type receptor (ANOVA and Dunnett’s test; **p < 0.01, ***p < 0.001). Values for wild-type, A/F, and W/F receptors are from Ren et al. (2013).