Table 1.

Effects of carbamazepine and quinpirole on physiological parameters

	Vehicle				Carbamazepine
	Saline		Quinpirole		Saline		Quinpirole
	Before	After	Before	After	Before	After	Before	After
Body temperature (°C)	36.5 ± 0.2	36.1 ± 0.2	36.4 ± 0.3	36.6 ± 0.3	36.5 ± 0.2	36.8 ± 0.4	36.5 ± 0.5	36.7 ± 0.2
Heart rate (beats/min)	384 ± 40	410 ± 34	441 ± 21	442 ± 31	417 ± 30	423 ± 23	421 ± 18	427 ± 18
Arterial blood pressure (mm Hg)
Systolic	149 ± 7	152 ± 6	160 ± 7	154 ± 13	142 ± 13	144 ± 11	142 ± 6	149 ± 12
Diastolic	94 ± 12	92 ± 8	103 ± 9	95 ± 12	99 ± 5	97 ± 7	105 ± 5	102 ± 7
pH	7.461 ± 0.024	7.435 ± 0.012	7.465 ± 0.021	7.451 ± 0.024	7.447 ± 0.021	7.368 ± 0.182	7.462 ± 0.012	7.441 ± 0.012
pO2 (mm Hg)	94.7 ± 12.5	97.2 ± 4.7	97.1 ± 10.0	108 ± 18.0	94.4 ± 6.8	98.5 ± 3.9	99.6 ± 5.0	103.2 ± 3.8
pCO2 (mm Hg)	37.4 ± 3.6	42.4 ± 2.2	37.2 ± 3.1	35.5 ± 6.3	39.1 ± 2.6	42.4 ± 3.2	37.2 ± 2.0	39.9 ± 1.8
Orofacial activity duration (s)
Orofacial activity				15 ± 4				14 ± 3
Calm period				34 ± 5				36 ± 4

Values are means ± SD (n = 6) measured before and 11 min after saline or quinpirole (1 mg/kg, i.v.) injection. None of these physiological parameters was statistically significantly affected by chronic carbamazepine or quinpirole administration