Table 2.
Transgenic Mouse Models Targeting Disease Mechanisms Associated with Atrial Fibrillation
| Transgenic mouse model | Mechanism | AF features observed | Reference(s) |
|---|---|---|---|
| Constitutive TGF-beta1 activation |
Elevated profibrotic signaling |
Atrial fibrosis, AF inducibility | (244) |
| ACE overexpression | Atrial enlargement, atrial fibrosis, AF |
(259) | |
| JDP2 overexpression | Atrial dilatation | (115) | |
| Rho-A overexpression | Cardiac disease associated AF |
DCM, atrial dilation, bradycardia, AV block, HF, AF |
(205) |
| Junctin overexpression | DCM, atrial dilation, bradycardia, enlarged left ventricle, AF |
(98) | |
| MURC overexpression | Atrial dilation, AV block, AF | (171) | |
| TNF-a overexpression | DCM, atrial fibrosis, HF, AF | (204, 208) | |
| CREM overexpression | HCM, atrial enlargement, atrial and ventricular hypertrophy; AF |
(158) | |
| Juncate-1 overexpression | HCM, atrial enlargement, ventricular hypertrophy, bradycardia, AF |
(99) | |
| Rac1 overexpression | HCM, AF | (2) | |
| HopX overexpression | HCM, atrial fibrosis, AF inducibility | (146) | |
| Constitutively active Gaq | HCM, left atrial dilatation, and fibrosis; AF under anaesthesia |
(94) | |
| Connexin 40 knockout | Electrical remodeling | AF inducibility | (86) |
| Kir2.1 overexpression | Bradycardia, PVCs, AV block, AF | (136) | |
| Cav1.3 knockout | Bradycardia, AV block, atrial flutter, AF |
(154, 273) | |
| KCNE1 knockout | AF | (236) | |
| NUP155 heterozygous knockout |
AF | (271) | |
| KCNE1-KCNQ1 fusion protein overexpression |
AF inducibility | (206) | |
| FKBP12.6 knockout | AF inducibility | (228) | |
| R176Q mutation of RYR2; RYR2-S2814A knock-in |
Increased AF inducibility with R176Q mutation; decreased AF inducibility with S2814A mutation |
(35) |