Table 6. Glutamate response time course of GluN2A-P552R equivalent amino acid changes in GluN1 and GluN2B.
| WT GluN1/GluN2A | GluN1-P557R/GluN2A | WT GluN1/GluN2B | GluN1/GluN2B-P553R | |
|---|---|---|---|---|
| Amplitude (peak, pA/pF) | 83 ± 29 | 9.9 ± 4.2* | 31 ± 6.9 | 24 ± 13 |
| Amplitude (SS, pA/pF) | 52 ± 16 | 8.4 ± 3.5* | 23 ± 5.3 | --- |
| ISS/IPEAK% | 68 ± 3.0% | 89 ± 4.1%* | 74 ± 2.5% | --- |
| Rise time (ms) | 10 ± 0.8 | 10 ± 1.7 | 15 ± 3.2 | 1033 ± 28* |
| τFAST (ms) | 39 ± 5.1 | 337 ± 37* | 410 ± 62 | 2992 ± 450* |
| τSLOW (ms) | 559 ± 120 | 696 ± 108 | 1370 ± 185 | 8797 ± 2764* |
| %τFAST | 96 ± 1.7% | 81 ± 6.0%* | 62 ± 6.0% | 63 ± 13% |
| τW (ms) | 54 ± 5.7 | 395 ± 32* | 765 ± 66 | 4590 ± 417* |
| n | 9 | 8 | 11 | 8 |
Data are from human NMDARs.
* p < 0.05 compared to corresponding WT, unpaired t-test.
See S7 Table for p values.