Table 3. Disease Severity measures in Hospitalized Children with Lower Respiratory Tract Infection, by Virus Type (HMPV vs RSV) and Infection Status (single virus infection vs co-detection).

	HMPV				RSV				HMPV vs RSV, P
	Total (n = 171)	Single (n = 106)	Co-detection (n = 65)	P	Total (n = 859)	Single (n = 540)	Co-detection (n = 319)	P	Single (n = 646)	Co-detection (n = 384)
Oxygen treatment, any	102 (60)	64 (60)	38 (58)	0.804	542/857 (63)	351/539 (65)	191/318 (60)	0.138	0.351	0.810
Oxygen (days), median (IQR)a	4.0 (2.0–6.0)	3.0 (2.0–6.0)	4.0 (2.0–6.5)	0.571	3.0 (2.0–5.0)	3.0 (2.0–5.0)	3.0 (1.5–4.5)	0.572	0.073	0.022
Resp. support, any	23 (13)	15 (14)	8 (12)	0.732	108 (13)	77 (14)	31 (10)	0.056	0.977	0.529
Resp. support, non-invasive	21 (12)	14 (13)	7 (11)	0.637	105 (12)	75 (14)	30 (9)	0.053	0.852	0.734
Resp. support, invasive	8 (5)	5 (5)	3 (5)	1.0	12 (1)	11 (2)	1 (0)	0.038	0.160	0.016
PICU admission	20 (12)	14 (13)	6 (9)	0.432	90 (10)	65 (12)	25 (8)	0.052	0.737	0.707
Length of stay, median (IQR)	4.0 (2.0–6.0)	4.0 (2.8–6.0)	4.0 (2.0–6.0)	0.860	4.0 (2.0–6.0)	4.0 (2.0–6.0)	4.0 (2.0–6.0)	0.654	0.940	0.969
Length of stay ≥ 6 days	49 (29)	30 (28)	19 (29)	0.896	238 (28)	149 (28)	89 (28)	0.923	0.881	0.828
Severity score, median (IQR)	1.0 (0.0–2.0)	1.0 (0.0–2.0)	1.0 (0.0–2.0)	0.885	1.0 (0.0–2.0)	1.0 (0.0–2.0)	1.0 (0.0–2.0)	0.191	0.496	0.951
Severity score ≥ 2	48 (28)	30 (28)	18 (28)	0.931	242 (28)	158 (29)	84 (26)	0.357	0.843	0.821

Data presented as absolute numbers and percent in parenthesis, if otherwise not specified. Fractions are provided when sample size deviates from the given values.

^aData from 99 hMPV-infected

(61 single and 38 co-detected) and 525 RSV-infected (340 single and 185 co-detected).

HMPV indicates human metapneumovirus; RSV, respiratory syncytial virus; IQR, interquartile range; PICU, pediatric intensive care unit.