Table 4. The cost-effectiveness of 12- and 24-month HPV testing, compared to 12-month HPV testing only, in women with OHR HPV and cytology ASC-US/LSIL.
Incremental cost-effectiveness ratio (ICER) of 12- and 24-month follow-up compared to 12-month follow-up only (A$/ LYS) | ||
---|---|---|
Unvaccinated cohorts | Cohorts offered vaccination | |
12 and 24m follow-up for all ages* | $ 238,000 | $228,000 |
12m follow-up for women aged less than 35, then 12 and 24m follow-up for women aged 35+ | $147,000 | $143,000 |
12m follow-up for women aged less than 45, then 12 and 24m follow-up for women aged 45+ | $97,000 | $ 94,000 |
12m follow-up for women aged less than 55, then 12 and 24m follow-up for women aged 55+ | $72,000 | $71,000 |
12m follow-up for women aged less than 65, then 12 and 24m follow-up for women aged 65+ | Extended dominated | Extended dominated |
LYS = life-years saved.
*The ICER for immediate colposcopy for all ages was calculated compared to 12-month follow-up for all ages. If the ICER was instead compared to immediate colposcopy for women aged 35+ years (which was the next most effective strategy), then the calculated ICER increased, and was >$300,000/LYS for both unvaccinated cohorts and cohort offered vaccination.
Extended dominated = the strategy has a higher ICER than a more effective strategy.