Table 2. Comparison of the detection of vertebral metastases with and without CAD.

	Reader A		Reader B
	CAD (–)	CAD (+)	CAD (–)	CAD (+)
Number detected	47	57	40	44
Number of true positives	33	38	36	39
Number of false positives	14	19	4	5
Number of false negatives	13	8	10	7
Sensitivity	0.717	0.826	0.783	0.848
Specificity	0.981	0.974	0.995	0.993
AUC on ROC curve analysis	0.849*	0.902*	0.889	0.910

AUC, area under the curve; ROC, receiver operating characteristic; CAD, computer-aided diagnosis

*indicates a significant difference between CAD (–) and CAD (+) (p = 0.021)