Table 3. Cox proportional hazards analysis for VAF.
| Variable | HR (95% CI) | P-value |
|---|---|---|
| Δ(MPV/P ratio)3mo-baseline (per 1) | 1.19 (1.15–1.24) | < 0.001 |
| Age (per 1 y) | 1.03 (1.00–1.07) | 0.04 |
| Male (vs. female) | 0.49 (0.24–0.98) | 0.04 |
| Diabetes | 25.29 (3.47–184.40) | 0.001 |
| Coronary artery disease | 1.87 (0.98–3.58) | 0.06 |
| Cerebrovascular disease | 2.37 (0.99–5.67) | 0.05 |
| Arteriovenous graft (vs. arteriovenous fistula) | 8.57 (4.03–18.24) | < 0.001 |
| Previous VAF | 8.63 (3.61–20.64) | < 0.001 |
| Antiplatelet drugs use | 0.54(0.28–1.02) | 0.06 |
| Hemoglobin (g/dL) | 0.94 (0.73–1.22) | 0.65 |
| Platelet (per 103/ μL) | 1.00 (0.99–1.01) | 0.83 |
| MPV (fL) | 0.84 (0.49–1.45) | 0.52 |
| Albumin (g/dL) | 0.54 (0.25–1.17) | 0.12 |
| Triglyceride (mg/dL) | 1.00 (0.99–1.01) | 0.23 |
| Total cholesterol (mg/dL) | 1.01 (0.99–1.01) | 0.37 |
| Calcium (per 1mg/dL) | 0.42 (0.53–1.31) | 0.42 |
| Phosphate (per 1mg/dL) | 1.00 (0.83–1.22) | 0.98 |
| PTH (per 1pg/mL) | 0.99 (0.99–1.00) | 0.92 |
| Kt/V (per 1) | 0.85 (0.24–2.99) | 0.85 |
Abbreviations: VAF, vascular access failure; MPV, mean platelet volume; PTH, parathyroid hormone; HR, hazard ratio; CI, confidence interval.
Unit of MPV/P ratio is fL/million platelets/μL blood.
Δ(MPV/P ratio)3mo-baseline was calculated as MPV/P ratio at 3months—MPV/P ratio at baseline.