Table 4. Multivariate Cox proportional hazards analysis for VAF.

Cox model	Δ(MPV/P ratio)3mo-baseline (per 1)
	HR (95% CI)	P-value
Unadjusted	1.19 (1.15–1.24)	< 0.001
Model 1	1.16 (1.11–1.22)	< 0.001
Model 2	1.15 (1.10–1.21)	< 0.001

Abbreviations: VAF, vascular access failure; MPV, mean platelet volume HR, hazard ratio; CI, confidence interval.

Unadjusted: crude relative risk

Model 1: adjusted for age, sex, diabetes, coronary artery disease, cerebrovascular disease, and vascular access type

Model 2: model 1 plus adjustment for previous VAF and antiplatelet drugs use.

Unit of MPV/P ratio is fL/million platelets/μL blood.

Δ(MPV/P ratio)_3mo-baseline was calculated as MPV/P ratio at 3months—MPV/P ratio at baseline.