. Author manuscript; available in PMC: 2017 Nov 1.

Published in final edited form as: Am J Geriatr Psychiatry. 2016 Apr 27;24(11):1105–1116. doi: 10.1016/j.jagp.2016.04.003

Table 2.

Type of Antidepressant use by Restless Legs Syndrome Category, n (%)

Medication	All (N= 981)	No RLS (N= 815)	0<IRLSS≤12 (N= 85)	IRLSS>12 (N= 82)	P-value, χ² [2, N=981]	P-trend, Z
Antidepressant use	99 (10.09)	74 (9.09)	8 (9.41)	17 (20.73)	p=0.004, χ²=11.17	p=0.003, Z=−2.99
Trazodone	23 (2.34)	17 (2.09)	0	6 (7.32)	p=0.004, χ²=11.13	p=0.03, Z=−2.18
Bupropion	14 (1.43)	13 (1.60)	0	1 (1.22)	p=0.49, χ²=1.42	p=0.48, Z=0.70
Venlafaxine	2 (0.20)	1 (0.12)	0	1 (1.22)	p=0.10, χ²=4.59	p=0.08, Z=−1.77
Nefazodone	1 (0.10)	1 (0.12)	0	0	p=0.90, χ²=0.21	p=0.67, Z=0.43
Selegiline	1 (0.10)	1 (0.12)	0	0	p=0.90, χ²=0.21	p=0.67, Z=0.43
Rasagiline	2 (0.20)	0	0	2 (2.44)	p<.0001, χ²=21.97	p<.0001, Z=−4.14
Amitriptyline	9 (0.92)	6 (0.74)	1 (1.18)	2 (2.44)	p=0.29, χ²=2.44	p=0.13, Z=−1.52
Imipramine	1 (0.10)	0	0	1 (1.22)	p=0.004, χ²=10.97	p=0.003, Z=−2.93
Mirtazapine	10 (1.02)	9 (1.11)	1 (1.18)	0	p=0.63, χ²=0.93	p=0.42, Z=0.82
Doxepin	1 (0.10)	1 (0.12)	0	0	p=0.90, χ²=0.21	p=0.67, Z=0.43
Nortriptyline	1 (0.10)	1 (0.12)	0	0	p=0.90, χ²=0.21	p=0.67, Z=0.43
Fluoxetine	15 (1.53)	13 (1.60)	1 (1.18)	1 (1.22)	p=0.93, χ²=0.15	p=0.73, Z=0.35
Paroxetine	7 (0.71)	5 (0.61)	2 (2.35)	0	p=0.14, χ²=3.93	p=0.89, Z=−0.14
Sertraline	12 (1.22)	8 (0.98)	1 (1.18)	3 (3.66)	p=0.11, χ²=4.42	p=0.05, Z=−1.92
Citalopram	20 (2.04)	16 (1.97)	2 (2.35)	2 (2.44)	p=0.94, χ²=0.13	p=0.73, Z=−0.35
Duloxetine	2 (0.20)	2 (0.25)	0	0	p=0.81, χ²=0.41	p=0.55, Z=0.60
Escitalopram	6 (0.61)	5 (0.61)	0	1 (1.22)	p=0.60, χ²=1.02	p=0.74, Z=−0.33

P-values from a chi-square test or from a Cochran-Armitage test for trend.

Abbreviations: IRLSS, International Restless Legs Syndrome Rating Scale score.