Table 3.
Adjusted Associations of Restless Legs Syndrome and Depression, Odds Ratio (95% Confidence Interval), Wald χ2 test statistic.
| Model | No RLS (n=815) |
0<IRLSS≤12 (n=85) |
IRLSS>12 (n=82) |
p-trend χ2 value |
|---|---|---|---|---|
| Minimally adjusteda | 1.00 (reference) | 0.81 (0.24, 2.71), χ2=0.12 | 3.06 (1.42, 6.58), χ2=8.15 | p=0.01, χ2=6.24 |
| Multivariate adjustedb | 1.00 (reference) | 0.93 (0.27, 3.17), χ2=0.02 | 2.85 (1.23, 6.64), χ2=5.92 | p=0.03, χ2=4.78 |
| Multivariateb + antidepressant use | 1.00 (reference) | 0.92 (0.27, 3.17), χ2=0.02 | 2.60 (1.10, 6.13), χ2=4.75 | p=0.05, χ2=3.82 |
| Multivariateb + sleep efficiency | 1.00 (reference) | 0.88 (0.25, 3.06), χ2=0.04 | 2.55 (1.08, 6.03), χ2=4.54 | p=0.06, χ2=3.57 |
| Multivariateb + sleep latency | 1.00 (reference) | 0.91 (0.26, 3.11), χ2=0.03 | 2.61 (1.11, 6.11), χ2=4.86 | p=0.05, χ2=3.89 |
a
adjusted for age and site, Wald χ2 [1, N=982].
b
adjusted for age, site, race (white vs. nonwhite), body mass index, alcohol use, caffeine intake, smoking status, physical activity, cognitive function, history of stroke, history of diabetes, history of myocardial infarction or congestive heart failure, use of benzodiazepines, use of dopamenergics, education, apnea-hypopnea index, Wald χ2 [1, N=945].
Bolded odds ratios and 95% confidence intervals are p<0.05 compared to the reference.
Abbreviations, IRSS=International RLS Study Group Severity Scale.