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. Author manuscript; available in PMC: 2017 Oct 26.
Published in final edited form as: Cell Syst. 2016 Sep 22;3(4):395–403.e4. doi: 10.1016/j.cels.2016.08.009

Figure 3. Multiplexed Ubiquitylome Analysis Monitors Cellular Response to Btz over Nine Time Points.

Figure 3

(A) Experimental design of Btz treatment time course is shown.

(B) Summary statistics for the experiment analyzing the samples in (A) are shown.

(C) Global ubiquitylome changes in response to treatment with Btz are shown.

(D) Principal-component analysis of changes in ubiquitylation upon Btz treatment is shown.

(E) Time-dependent changes in ubiquitylation of ubiquitinated lysine residues on UB are shown.

(F) Ubiquitylation changes of proteins involved in cancer pathways upon treatment with Btz are shown.