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. Author manuscript; available in PMC: 2017 Jan 17.
Published in final edited form as: Biol Psychiatry. 2014 Jul 15;77(4):335–344. doi: 10.1016/j.biopsych.2014.07.008

Figure 4.

Figure 4

Effects of a retinoic acid receptor (RAR)α agonist (CD1556) and antagonist (Ro 41-5253) on neural differentiation of adult dentate gyrus-derived neural precursor (ADP) cells in vitro. (A) Retinoic acid (RA) and CD1556 (2 μmol/L), a selective RARα agonist, induced neural differentiation but the latter had a more robust effect (t6 = 4.651, p < .01) in ADP cells from the animal facility reared group. (B) Ro 41-5253 (1 μmol/L), a selective RARα antagonist, attenuated neural differentiation induced by RA of ADP cells in the animal facility reared group (t6 = 11.370, p < .0001). Data are shown as the means ± SEM. Statistical significance is shown at **p < .01 or ****p < .0001. DAPI, 4′,6-diamidino-2-phenylindole.