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Hypothetical epigenetic mechanisms underlying the effects of neonatal maternal separation (NMS) on neural differentiation of adult dentate gyrus-derived neural precursor cells. NMS reduces neural differentiation by decreasing retinoic acid receptor α (R) expression via increased DNA methyltransferase 1 (D) expression and DNA methylation (M) at a retinoic acid receptor α promoter. AFR, animal facility reared.
