Table 1.

Plasma mean (± SEM) levels of catechols (nmol/lL) and catechol ratios in patients with familial dysautonomia (FD) and in control subjects. Data are shown for FD patients upon initial evaluation and after 13 years of follow-up

Compound	FD initial	FD follow-up	Control	P Initial, Follow-up
DA	0.14 ± 0.02	0.25 ± 0.06	0.03 ± 0.01	0.0004, 0.0002
NE	1.41 ± 0.17	1.76 ± 0.51	1.20 ± 0.10	0.21, 0.70
EPI	0.09 ± 0.03	0.49 ± 0.18	0.13 ± 0.02	0.06, 0.45
DOPA	9.68 ± 0.58	11.71 ± 1.71	7.93 ± 0.26	0.013, 0.0006
DOPAC	6.83 ± 2.47	7.56 ± 1.01	8.09 ± 0.70	0.07, 0.77
DHPG	2.53 ± 0.31	2.49 ± 0.43	4.92 ± 0.23	0.0004, 0.0004
DA:NE	0.10 ± 0.01	0.34 ± 0.23	0.02 ± 0.00	< 0.0001, 0.0003
NE:DHPG	0.59 ± 0.08	0.61 ± 0.12	0.25 ± 0.01	< 0.0001, < 0.0001
DA:DOPAC	0.029 ± 0.006	0.033 ± 0.009	0.004 ± 0.001	< 0.0001, < 0.0001
DOPA:DHPG	4.05 ± 0.32	4.89 ± 0.24*	1.72 ± 0.06	< 0.0001, < 0.0001
DOPAC:DHPG	2.49 ± 0.57	3.35 ± 0.48	1.65 ± 0.12	0.03, < 0.0001

Notes: DA = dopamine; DHPG = dihydroxyphenylglycol; DOPA = L-3,4-dihydroxyphenylalanine; DOPAC = dihydroxyphenylacetic acid; EPI = epinephrine; NE = norepinephrine.

^*Different from initial, P = 0.015