Figure 1.

Image processing and analysis pipeline. Spectral processing in Metabolite Imaging and Data Analysis System (MIDAS) includes signal normalization, tissue segmentation, quality evaluation, and registration of metabolite maps to anatomical images. Anatomical, metabolite, and clinical images are imported into VelocityAI for coregistration and radiation therapy (RT) volume contouring. Contralateral normal-appearing white matter is segmented using white matter probability maps to determine fold changes in spectroscopic magnetic resonance imaging (sMRI) metabolites. sMRI maps depicting standardized metabolite changes are then viewed alongside clinical images to assist in target delineation.