TABLE 1.

Number of cells and population kinetic parameters in the CVEU

	Control		Omomyc		Within 0–10 h after AraCa		Beyond 10 h after AraCb
Description	Duodenum	Ileum	Duodenum	Ileum	Duodenum	Ileum	Duodenum	Ileum
CVEU length (cells)	99.7 ± 8.30	61.5 ± 7.18	98.8 ± 7.32	52.1 ± 7.36	93.4 ± 7.16	64.7 ± 10.6	101 ± 11.9	59.2 ± 9.25
Cell density in labeled strips (cells/10 µm)	1.25 ± 0.246	1.00 ± 0.129	1.01 ± 0.141	0.865 ± 0.112	0.848 ± 0.0841	0.917 ± 0.102	1.12 ± 0.192	0.778 ± 0.165
Labeled cells 2 h after BrdU (n)	8.2 ± 0.4	7.4 ± 0.4	6.1 ± 0.4	4.3 ± 0.5	0	0	8 ± 0.8	6.8 ± 0.3
Crypt–villus boundary; crypt compartment size (n cells): NCc	20 ± 2.0	19 ± 1.8	18 ± 0.8	16 ± 0.7	20d	20d	20 ± 1.0	20 ± 2
Specific cell proliferation rate or cell transfer rate to villus: δ (h−1) in Eq. 1	0.0760 ± 0.0147	0.0544 ± 0.00644	0.0547 ± 0.00665	0.0509 ± 0.00427	0.00891 ± 0.0128e	0.00136 ± 0.00698e	0.0864 ± 0.0144	0.0466 ± 0.00901
Crypt cell production rate or cell migration velocity at crypt–villus boundary: VC-V (cells/h)f	1.51 ± 0.325	1.03 ± 0.156	0.983 ± 0.126	0.813 ± 0.0768	0.174 ± 0.253e	0.0279 ± 0.154e	1.73 ± 0.300	0.934 ± 0.204
Migration velocity of labeled front along villus: VLF (µm/h) in Eq. 6	9.00 ± 0.465	5.96 ± 0.379	7.24 ± 0.190	5.29 ± 0.235	−0.798 ± 0.942e	0.0765 ± 0.477e	8.68 ± 0.655	6.09 ± 1.15

Average number of cells and standard deviation of 3–6 samples from different mice and estimates and se of fitted parameters.

^aEstimated with data obtained within the first 10 h after AraC injection.

^bEstimated with data obtained after the first 10 h after AraC injection.

^cEstimated as the position at which the fraction of BrdU labeled cells, 2 h after injection, takes values smaller than 0.01.

^dAssumed from BrdU data observed after the first 10 h after AraC injection.

^eNot significantly different from 0.

^fEstimated as .