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. Author manuscript; available in PMC: 2017 Jan 17.
Published in final edited form as: J Med Chem. 2008 Jul 17;51(15):4518–4528. doi: 10.1021/jm800175e

Scheme 1.

Scheme 1

Synthesis of 2′,3′-Protected Nucleoside-5′-Carboxylic Acidsa

a Reagents and conditions: (a) p-methoxybenzaldehyde, ZnCl2, dry THF, room temp, 48 h; (b) TEMPO, bis(acetoxy)iodobenzene, H2O/MeCN = 1:1, room temp, 3 h.