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. Author manuscript; available in PMC: 2017 Jan 17.
Published in final edited form as: J Med Chem. 2008 Jul 17;51(15):4518–4528. doi: 10.1021/jm800175e

Scheme 2.

Scheme 2

Synthesis of ω-Aminoalkylcarboxamidoalkyl- and ω-Aminoalkylcarboxamido-p-benzyl-Substituted Phosphonic Acid Diethyl Estersa

a Reagents and conditions: (a) dry THF, N-methylmorpholine, ClCO2CH2CH(CH3)2, –25 °C to room temp, 3 h; (b) 4 N HCl in dry dioxane, room temp, 2h.