Table 1.
Baseline characteristics of the study groups as a whole and by ethnicity.
| Entire Group (N=3419) | Black (N=1792) | White (N=1030) | Hispanic (N=597) | P-Value for ethnicity | |
|---|---|---|---|---|---|
| Age, years (SD) | 43.8 (10.1) | 44.5 (10.2) | 44.7 (10.0) | 40.0 (9.2) | <0.001 |
| Male, N (%) | 1501 (43.9) | 755 (42.1) | 496 (48.2) | 250 (42.0) | 0.004 |
| BMI | 30.8 (7.6) | 31.6 (8.2) | 29.0 (6.7) | 30.3 (6.6) | <0.001 |
| HTN, N (%) | 963 (28.2) | 660 (36.8) | 218 (21.2) | 85 (14.2) | <0.001 |
| Diabetes, N (%) | 393 (11.5) | 254 (14.2) | 66 (6.4) | 71 (11.9) | <0.001 |
| Current smoking, N (%) | 1004 (29.4) | 598 (33.4) | 284 (27.6) | 122 (20.4) | <0.001 |
| Laboratory variables | |||||
| Lp(a), nmol/L | 49.9 (19.6-110.5) | 79.0 (43-132) | 26.9 (10-69) | 21.3 (9-46) | <0.001 |
| OxPL-apoB, RLU | 4025 (2564-8734) | 6445 (3419-11389) | 3014 (2233-5306) | 2689 (2058-3766) | <0.001 |
| Size of major isoform, # kringles | 24 (19.5-28) | 23.0 (20-26) | 24.0 (19-29) | 27.0 (21-32) | <0.001 |
| Total Cholesterol, mg/dl | 180.3 (39.7) | 177.7 (40.3) | 183.6 (38.3) | 182.3 (40.1) | <0.001 |
| LDL-C, mg/dl | 106.2 (35.5) | 104.7 (36.8) | 108.2 (34.3) | 107.2 (33.3) | 0.029 |
| HDL-C, mg/dl | 49.9 (14.9) | 52.3 (15.4) | 48.4 (15.1) | 45.7 (11.2) | <0.001 |
| VLDL-C, mg/dl | 24.2 (18.9) | 20.8 (17.7) | 26.9 (18.1) | 29.4 (21.5) | <0.001 |
| Triglycerides, mg/dl | 96.0 (67-146) | 85.0 (62-123) | 109.0 (75-166) | 119.0 (81-176) | <0.001 |
| Minor allele frequency, N (%) | |||||
| rs3798220 | 324 (9.48) | 27 (1.51) | 44 (4.27) | 253 (42.38) | <0.001 |
| rs10455872 | 213 (6.22) | 33 (1.84) | 147 (14.27) | 33 (5.53) | <0.001 |
| rs9457951 | 615 (17.99) | 590 (32.92) | 4 (0.0039) | 21 (3.52) | <0.001 |
| rs1801693 | 1341 (40.2) | 417 (23.9) | 532 (52.9) | 392 (67.1) | <0.001 |
| rs41272110 | 455 (13.4) | 80 (4.48) | 272 (26.72) | 103 (17.37) | <0.001 |
| G+1/inKIV-8A | 186 (5.5) | 102 (5.74) | 55 (5.40) | 29 (4.94) | 0.75 |
Values are given as mean (SD) or median (IQR). For rs1801693, rs41272110 and G+1/inKIV-8A 3379, 3333 and 3395 subjects were genotyped.