Table 2.
Relationship of LPA rs3798220, rs10485774 and rs9459571 to Lp(a), apolipoprotein(a) isoforms and OxPL-apoB.
| Black | ||||
|---|---|---|---|---|
|
|
||||
| rs3798220 | TT (N = 1765) | TC (N= 27) | CC (N = 0) | P-Value |
| Lp(a), nmol/L | 79.3 (43.8-132.2) | 49.1 (13.5-122.6) | - | 0.15 |
| OxPL-apoB, RLU | 6507 (3510-11416) | 4305 (2501-8733) | - | 0.11 |
| Major apolipoprotein(a) isoform, #KIV repeats | 23.0 (20-26) | 23.0 (21-33) | - | 0.042 |
| White | ||||
|
|
||||
| TT (N = 985) | TC (N= 43) | CC (N = 1) | ||
|
|
||||
| Lp(a), nmol/L | 25.9 (9.5-58.1) | 187.3 (113.4-229.1) | 197.1 (-) | <0.001 |
| OxPL-apoB, RLU | 2963 (2217-4701) | 12493 (8521-16202) | 13222 (-) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 24.5 (19-29) | 17.0 (17-19) | 17.0 (-) | <0.001 |
| Hispanic | ||||
|
|
||||
| TT (N = 343) | TC (N= 212) | CC (N = 41) | ||
|
|
||||
| Lp(a), nmol/L | 25.2 (10.2-61.0) | 18.8 (8.1-36.6) | 13.2 (6.4-22.9) | <0.001 |
| OxPL-apoB, RLU | 2873 (2145-4567) | 2586 (1972-3360) | 2445 (1777-2901) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 25.0 (20-30) | 30.25 (24-34) | 33.0 (31.5-34) | <0.001 |
| Black | ||||
|
|
||||
| rs10485774 | AA (N = 1759) | AG (N= 33) | GG (N = 0) | P-Value |
|
| ||||
| Lp(a), nmol/L | 77.9 (43.4-132.1) | 207.0 (117-261.9) | - | <0.001 |
| OxPL-apoB, RLU | 6314 (3473-11300) | 11854 (6397-17005) | - | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 23.0 (20-26) | 17 (16-17.5) | - | <0.001 |
| White | ||||
|
|
||||
| AA (N = 882) | AG (N= 139) | GG (N = 8) | ||
|
|
||||
| Lp(a), nmol/L | 21.2 (8.1-41.8) | 141.4 (108.4-172.3) | 219.6 (205.6-276.9) | <0.001 |
| OxPL-apoB, RLU | 2826 (2134-3895) | 7949 (5496-10745) | 12534 (8792-16924) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 25.5 (21-29) | 17.0 (16-18) | 17.25 (16.1-17.5) | <0.001 |
| Hispanic | ||||
|
|
||||
| AA (N = 563) | AG (N= 31) | GG (N = 2) | ||
|
|
||||
| Lp(a), nmol/L | 19.6 (8.1-40.7) | 151.7 (102.6-198.2) | 151.3 (-) | <0.001 |
| OxPL-apoB, RLU | 2602 (2046-3530) | 7966 (4773-12056) | 8583 (-) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 28.0 (22-32) | 17.0 (16-17) | 17.0 (-) | <0.001 |
| Black | ||||
| rs9459571 | CC (N = 1202) | CG (N= 547) | GG (N = 43) | P-Value |
|
| ||||
| Lp(a), nmol/L | 73.8 (40.6-121.9) | 94.4 (50.8-153.4) | 97.0 (62.2-186.6) | <0.001 |
| OxPL-apoB, RLU | 5502 (3247-9864) | 8602 (4241-14223) | 8032 (5052-17154) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 22.5 (20-26) | 24.0 (20-27) | 24.0 (19-24) | 0.008 |
| White | ||||
| CC (N = 1025) | CG (N= 3) | GG (N = 1) | ||
|
|
||||
| Lp(a), nmol/L | 26.7 (10.1-68.7) | 89.8 (-) | 35.8 (-) | 0.38 |
| OxPL-apoB, RLU | 3015 (2233-5286) | 8223 (-) | 1952 (-) | 0.43 |
| Major apolipoprotein(a) isoform, #KIV repeats | 24.0 (19-29) | 26.0 (-) | 27.0 (-) | 0.85 |
| Hispanic | ||||
|
|
||||
| CC (N = 575) | CG (N= 20) | GG (N = 1) | ||
|
|
||||
| Lp(a), nmol/L | 20.6 (8.2-43.7) | 76.4 (32.6-146.6) | 507 (-) | <0.001 |
| OxPL-apoB, RLU | 2656 (2053-3674) | 6508 (2993-11918) | 18675 (-) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 28.0 (21-32) | 21.5 (6508) | 14 (-) | 0.003 |
|
| ||||
| Black | ||||
| rs1801693 | AA (N = 1326) | AG (N= 391) | GG (N = 26) | P-Value |
|
| ||||
| Lp(a), nmol/L | 84.3 (49.5-134.7) | 55.7 (30.6-116.5) | 44.2 (12.0-98.0) | <0.001 |
| OxPL-apoB, RLU | 7066 (3884-11613) | 4482 (2893-9923) | 3836 (2459-9549) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 23.0 (20-26) | 24.0 (20-28) | 25.0 (19.75-32) | <0.001 |
| White | ||||
| AA (N = 474) | AG (N= 434) | GG (N = 98) | ||
|
|
||||
| Lp(a), nmol/L | 28.5 (11.7-80.1) | 23.8 (8.6-57.1) | 24.9 (4.2-108.2) | 0.025 |
| OxPL-apoB, RLU | 3104 (2250-5773) | 2958 (2229-4635) | 3127 (2134-8486) | 0.29 |
| Major apolipoprotein(a) isoform, #KIV repeats | 23.25 (18-29) | 25.0 20-28 | 24.25 (18-29) | 0.068 |
| Hispanic | ||||
|
|
||||
| AA (N = 192) | AG (N= 266) | GG (N = 126) | ||
|
|
||||
| Lp(a), nmol/L | 29.5 (13.4-78.5) | 19.6 (6.8-40.6) | 16.4 (7.8-36.8) | <0.001 |
| OxPL-apoB, RLU | 2898 (2172-3587) | 2739 (2049-3587) | 2520 (1850-3570) | 0.016 |
| Major apolipoprotein(a) isoform, #KIV repeats | 24.0 (19-28) | 28.0 (23-33) | 31.0 (25.38-33.63) | <0.001 |
| Black | ||||
| rs41272110 | TT (N = 1704) | TG (N= 78) | GG(N = 2) | P-Value |
|
| ||||
| Lp(a), nmol/L | 79.4 (43.9-132.8) | 59.3 (31.4-124.8) | 60.5 (-) | 0.33 |
| OxPL-apoB, RLU | 6509 (3521-11428) | 4769 (2960-10707) | 6317 (-1) | 0.37 |
| Major apolipoprotein(a) isoform, KIV repeats | 23.0 (20-26.5) | 21.5 (18-25) | 22.5 (-) | 0.071 |
| White | ||||
| TT (N = 746) | TG (N= 258) | GG(N = 14) | ||
|
|
||||
| Lp(a), nmol/L | 26.4 (7.3-76.6) | 27.2 (13.7-58.4) | 24.9 (13.4-106.7) | 0.51 |
| OxPL-apoB, RLU | 3097 (265-5576) | 2920 (2096-5036) | 2575 (2170-4421) | <0.001 |
| Major apolipoprotein(a) isoform, #KIV repeats | 26.0 (19-29.5) | 20.25 (18-25.63) | 19.0 (18-20) | 0.56 |
| Hispanic | ||||
|
|
||||
| TT (N = 490) | TG (N= 99) | GG(N = 4) | ||
|
|
||||
| Lp(a), nmol/L | 20.6 (7.1-47.7) | 23.5 (14.1-33.9) | 21.4 (5.4-35.0) | 0.47 |
| OxPL-apoB, RLU | 2774 (2056-3962) | 2519 (2050-3468) | 2566 (2264-3117) | 0.62 |
| Major apolipoprotein(a) isoform, #KIV repeats | 28.5 (23-33) | 20.0 (19-26) | 19.5(19-22) | <0.001 |
|
| ||||
| Black | ||||
| G+1/inKIV-8A | GG(N = 1673) | GA N(= 98) | AA(N = 4) | P-Value |
|
| ||||
| Lp(a), nmol/L | 78.9 (43.5-131.5) | 77.6(50.8-153.4) | 70.4 (30.8-91.2) | 0.90 |
| OxPL-apoB, RLU | 6481 (3520-11305) | 5845 (3036-13624) | 5956 (2972-14026) | 0.99 |
| Major apolipoprotein(a) isoform, #KIV repeats | 23.0 (20-26) | 22.75 (20-26) | 25.5 (19.5-31.5) | 0.60 |
| White | ||||
| GG (N = 962) | GA(N= 52) | AA(N = 3) | ||
|
|
||||
| Lp(a), nmol/L | 26.4 (10.1-68.9) | 32.3 (9.0-92.2) | 37.5 () | 0.66 |
| OxPL-apoB, RLU | 3020 (2239-5296) | 2984 (2262-5648) | 1812 (-) | 0.63 |
| Major apolipoprotein(a) isoform, #KIV repeats | 24.0 (19-29) | 23.5 (17.25-27.75) | 19.0 (-) | 0.30 |
| Hispanic | ||||
|
|
||||
| GG (N = 558) | GA (N= 28) | AA(N = 1) | ||
|
|
||||
| Lp(a), nmol/L | 21.1 (8.7-45.4) | 24.8 (7.5-70.3) | 5.1 (-) | 0.72 |
| OxPL-apoB, RLU | 2720 (2070-3730) | 2593 (2134-4741) | 1708 (-) | 0.71 |
| Major apolipoprotein(a) isoform, #KIV repeats | 27.0 (21-32) | 28.0 (19.5-31.0) | 34.0 (-) | 0.43 |
Values are given as median (IQR).