Table 4.
Hazard Ratios for MACE According to Quartiles of Lp(a), OxPL-apoB and Size of the Major Apolipoprotein(a) Isoform with Sequential adjustment.
| Variable | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-Value Q1 vs. Q4 |
|---|---|---|---|---|---|
| Lp(a) | 1.00 | 1.21 (0.76-1.92) | 1.87 (1.22-2.88) | 2.44 (1.62-3.68) | <0.001 |
| Plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 1.30 (0.80-2.12) | 1.80 (1.13-2.87) | 2.35 (1.50-3.69) | <0.001 |
| Plus LPA SNPs | 1.00 | 1.28 (0.76-2.13) | 1.75 (1.07-2.88) | 2.43 (1.48-3.97) | <0.001 |
| Plus log2 apolipoprotein(a) major isoform | 1.00 | 1.23 (0.73-2.06) | 1.59 (0.94-2.68) | 2.06 (1.17-3.62) | 0.012 |
| Plus log2 OxPL-apoB | 1.00 | 1.23 (0.73-2.08) | 1.46 (0.79-2.69) | 1.69 (0.75-3.82) | 0.21 |
| OxPL-apoB | 1.00 | 0.79 (0.50-1.24) | 1.37 (0.92-2.03) | 1.78 (1.22-2.59) | 0.003 |
| Plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.86 (0.54-1.36) | 1.32 (0.87-2.00) | 1.89 (1.26-2.84) | 0.003 |
| Plus LPA SNPs | 1.00 | 0.85 (0.52-1.38) | 1.31 (0.84-2.04) | 1.80 (1.21-2.87) | 0.005 |
| Plus log2 apolipoprotein(a) major isoforms | 1.00 | 0.84 (0.51-1.36) | 1.17 (0.74-1.84) | 1.58 (0.99-2.51) | 0.056 |
| Plus log2 Lp(a) | 1.00 | 0.69 (0.42-1.15) | 0.74 (0.46-1.36) | 0.90 (0.48-1.69) | 0.73 |
| Major apolipoprotein(a) isoform size | 1.00 | 1.03 (0.72-1.47) | 0.97 (0.67-1.40) | 0.60 (0.38-0.86) | 0.007 |
| Plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.79 (0.55-1.14) | 0.77 (0.53-1.13) | 0.52 (0.34-0.80) | 0.003 |
| Plus LPA SNPs | 1.00 | 0.83 (0.55-1.24) | 0.76 (0.50-1.17) | 0.49 (0.30-0.78) | 0.003 |
| Plus log2 OxPL-apoB | 1.00 | 0.84 (0.56-1.27) | 0.94 (0.59-1.45) | 0.62 (0.37-1.05) | 0.076 |
| Plus log2 Lp(a) | 1.00 | 0.99 (0.64-1.52) | 1.05 (0.66-1.66) | 0.79 (0.65-1.37) | 0.40 |
Quartiles for Lp(a): Q1<19.6, Q2 >19.6 - <49.9, Q3 >49.9 - <110.5, Q4 >110.5 nmol/L. Quartiles for major isoform size: Q1<19.5, Q2 >19.5 - <24.0, Q3 >24.0 - <28.0, Q4 >28.0 Kringle IV repeats. Quartiles for OxPL-apoB: Q1<2564, Q2 >2564 - <4025, Q3 >4025 - <8734, Q4 >8734 RLU.