Table 5.
Hazard Ratios for MACE by Ethnicity According to Quartiles of Lp(a), OxPL-apoB and Size of the Major Apolipoprotein(a) Isoform with Sequential adjustment.
| Black | |||||
|---|---|---|---|---|---|
| Variable | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-Value Q1 vs. Q4 |
| Lp(a) plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 1.80 (0.73-4.43) | 2.37 (0.99-5.63) | 3.27 (1.27-7.11) | 0.012 |
| OxPL-apoB plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.86 (0.44-1.68) | 1.13 (0.63-2.02) | 1.54 (0.87-2.72) | 0.140 |
| Major apolipoprotein(a) isoform size plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.81 (0.52-1.25) | 0.76 (0.48-1.20) | 0.49 (0.27-0.88) | 0.017 |
| White | |||||
| Variable | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-Value Q1 vs. Q4 |
| Lp(a) plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.88 (0.42-1.88) | 1.31 (0.56-3.03) | 1.83 (0.88-3.80) | 0.105 |
| OxPL-apoB plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.54 (0.24-1.23) | 0.75 (0.34-1.63) | 0.57 (0.28-1.17) | 0.127 |
| Major apolipoprotein(a) isoform size plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.81 (0.52-1.25) | 0.76 (0.48-1.20) | 0.49 (0.27-0.88) | 0.017 |
| Hispanic | |||||
| Variable | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-Value Q1 vs. Q4 |
| Lp(a) plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 3.44 (0.55-21.7) | 2.29 (0.38-13.8) | 5.43 (0.79-37.2) | 0.085 |
| OxPL-apoB plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 1.66 (0.31-8.82) | 1.07 (0.10-11.2) | 13.4 (1.89-94.3) | 0.009 |
| Major apolipoprotein(a) isoform size plus sex, HTN, diabetes, smoking, age in deciles, BMI, LDL-C per 25 mg/dL, HDL-C per 10 mg/dL, log2 TG | 1.00 | 0.38 (0.04-3.80) | 0.68 (0.11-4.03) | 0.35 (0.06-1.91) | 0.23 |
Quartiles for Lp(a): Q1<19.6, Q2 >19.6 - <49.9, Q3 >49.9 - <110.5, Q4 >110.5 nmol/L. Quartiles for major isoform size: Q1<19.5, Q2 >19.5 - <24.0, Q3 >24.0 - <28.0, Q4 >28.0 Kringle IV repeats. Quartiles for OxPL-apoB: Q1<2564, Q2 >2564 - <4025, Q3 >4025 - <8734, Q4 >8734 RLU