Table 2.
Plasma Fatty Acid Levels Before and After Ivacaftor
| Fatty Acid | Before Ivacaftor | After Ivacaftor | p-value |
|---|---|---|---|
| Tetradecanoic acid (14:0) | 1.10 [0.80, 0.67] | 1.26 [0.67, 1.72] | 0.40 |
| Hexadecanoic acid (16:0) | 32.84 [30.96, 35.20] | 33.58 [30.69, 35.85] | 0.18 |
| Palmitoleic acid (16:1) | 2.29 [1.47, 3.04] | 1.74 [1.44, 2.69] | 0.02 |
| Octadecanoic acid (18:0) | 10.73 [9.02, 11.56] | 10.88 [9.76, 12.10] | 0.22 |
| Oleic acid (18:1 n-9) | 11.10 [9.34, 12.59] | 10.05 [8.69, 11.55] | 0.20 |
| Vaccenic acid (18:1 n-7) | 11.48 [10.62, 12.57] | 11.44 [10.14, 12.93] | 0.95 |
| Linoleic acid (18:2 n-6; LA) | 21.37 [18.71, 24.80] | 21.61 [18.31, 25.23] | 0.62 |
| α-linoleic acid (18:3 n-3) | 0.21 [0.15, 0.28] | 0.18 [0.13, 0.31] | 0.29 |
| Gamma-linoleic acid (18:3 n-6) | 0.36 [0.24, 0.42] | 0.40 [0.20, 0.60] | 0.17 |
| Eicosanoic acid (20:0) | 0.04 [0.03, 0.06] | 0.04 [0.03, 0.07] | 0.84 |
| Eicosenoic acid (20:1 n-9) | 0.12 [0.08, 0.15] | 0.12 [0.10, 0.17] | 0.48 |
| Eicosadienoic acid (20:2 n-6) | 0.12 [0.1, 0.15] | 0.14 [0.11, 0.17] | 0.004 |
| Mead acid (20:3 n-9) | 0.31 [0.23, 0.39] | 0.25 [0.20, 0.34] | 0.006 |
| Dihomo-gamma-linoleic acid (20:3 n-6) | 1.09 [0.97, 1.34] | 1.13 [0.94, 1.22] | 0.66 |
| Arachidonic Acid (20:4 n-6; AA) | 4.90 [4.30, 5.68] | 4.62 [3.56, 5.96] | 0.04 |
| Eicosapentaenoic acid (20:5 n-3) | 0.18 [0.12, 0.25] | 0.17 [0.11, 0.28] | 0.55 |
| Adrenic acid (22:4 n-6) | 0.12 [0.10, 0.16] | 0.11 [0.08, 0.14] | 0.19 |
| Docosapentaenoic acid (22:5 n-6) | 0.07 [0.05, 0.10] | 0.08 [0.04, 0.10] | 0.85 |
| Docosapentaenoic acid (22:5 n-3) | 0.20 [0.16, 0.25] | 0.18 [0.13, 0.23] | 0.004 |
| Docosahexaenoic acid (22:6 n-3; DHA) | 0.37 [0.29, 0.51] | 0.38 [0.3, 0.47] | 0.87 |
| LA × DHA | 8.32 [5.93, 12.53] | 7.95 [6.04, 10.8] | 0.55 |
| Triene/Tetraene (20:3n-9/20:4n-6) | 0.06 [0.05, 0.07] | 0.06 [0.05, 0.06] | 0.16 |
Data in units of mole percent and expressed as median [IQR]. Statistical testing by Wilcoxon signed rank test with significance set at p <0.05.