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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Cyst Fibros. 2016 Jul 26;16(1):132–138. doi: 10.1016/j.jcf.2016.07.006

Table 3.

Plasma Fatty Acid Levels Before and After Ivacaftor by Participant Age

Fatty Acid Before Ivacaftor After Ivacaftor
Palmitoleic acid (16:1) Pediatric 1.64 [1.03, 2.50] 1.53 [1.12, 2.03]
Adult 2.83 [1.78, 3.86]** 2.41 [1.67, 3.42]**†
Linoleic acid (18:2 n-6; LA) Pediatric 24.41 [19.72, 26.4] 22.8 [18.53, 26.78]
Adult 20.46 [18.23, 22.88]** 21.13 [18.31, 23.73]
Eicosadienoic acid (20:2 n-6) Pediatric 0.11 [0.09, 0.13] 0.14 [0.11, 0.16]††
Adult 0.14 [0.11, 0.18]* 0.15 [0.13, 0.18]
Mead acid (20:3 n-9) Pediatric 0.30 [0.24, 0.35] 0.24 [0.21, 0.31]†
Adult 0.32 [0.21, 0.41] 0.26 [0.2, 0.36]
Arachidonic acid (20:4 n-6) Pediatric 4.97 [4.44, 6.47] 4.62 [3.56, 6]††
Adult 4.82 [4.05, 5.49] 4.59 [3.3, 5.94]
Docosapentaenoic acid (22:5 n-3) Pediatric 0.23 [0.2, 0.27] 0.18 [0.14, 0.23]††
Adult 0.18 [0.13, 0.23] 0.17 [0.12, 0.23]
Docosahexaenoic acid (22:6 n-3; DHA) Pediatric 0.34 [0.29, 0.5] 0.36 [0.26, 0.43]
Adult 0.39 [0.3, 0.51] 0.44 [0.31, 0.57]
LA × DHA Pediatric 8.17 [5.37, 12.59] 7.72 [5.78, 9.34]
Adult 8.32 [6.03, 12.2] 9.44 [6.04, 10.86]
Triene/Tetraene (T:T) Pediatric 0.06 [0.05, 0.06] 0.05 [0.05, 0.06]
Adult 0.07 [0.04, 0.08] 0.06 [0.04, 0.07]

Data in units of mole percent and expressed as median [IQR]. Statistical testing by Wilcoxon signed rank test with significance set at p <0.05.