. Author manuscript; available in PMC: 2018 Jan 17.

Published in final edited form as: Chem Res Toxicol. 2016 Nov 16;30(1):162–176. doi: 10.1021/acs.chemrestox.6b00319

Table 5.

Nuclear Receptor Regulation by Human AKRs

human AKR	nuclear receptor ligand regulation	nuclear receptor target	change in gene expression
AKR1B10	all-trans-retinaldehyde → all-trans-retinol	RAR	decrease
AKR1B15	9-cis-retinaldhehyde → cis-retinol	RXR	decrease
AKR1C1	progesterone → 20α-hydroxyprogesterone	PR	decrease
AKR1C2	dihydrotestosterone → 3α-androstanediol	AR	decrease
AKR1C3	Δ⁴-androstene-3,17-dione → testosterone; 5α-androstane-3,17-dione → dihydrotestosterone	AR	increase
AKR1C3	estrone → 17β-estradiol	ER	increase
AKR1C3	11β-PGD₂ → PGF₂α	PPARγ	decrease
AKR1D1	bile-acid biosynthesis	FXR	increase