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. Author manuscript; available in PMC: 2018 Jan 17.
Published in final edited form as: Circulation. 2016 Nov 23;135(3):224–240. doi: 10.1161/CIRCULATIONAHA.116.023361

Table 3.

Measures of cardiac structure and function among ARIC participants with Stage A HF at Visit 5 stratified by the number of HF risk factors present.

Overall (n=3,192) 1 Risk Factor (n=868) 2 Risk Factors (n=908) 3 Risk Factors (n=789) 4 Risk Factors (n=570) Unadjusted P value Adjusted P value
LV structure
Wall thickness (cm) 0.93 [0.88, 1.00] 0.91 [0.85, 0.97] 0.93 [0.87, 0.99] 0.95 [0.89, 1.02] 0.96 [0.90, 1.04] <0.0001 <0.0001
Mass/height2.7 (g/m2.7) 33.3 [29.0, 37.2] 31.5 [27.4, 35.9] 32.9 [28.9, 36.8] 33.8 [29.7, 37.5] 35.3 [31.4, 38.8] <0.0001 <0.0001
EDV/BSA (ml/m2) 39.6 [34.5, 45.4] 40.9 [36.0, 46.6] 39.3 [34.7, 44.9] 39.0 [33.9, 44.7] 38.4 [33.3, 44.4] <0.0001 <0.0001
Systolic Function
LVEF (%) 66.7 [63.7, 69.9] 66.6 [63.7, 69.9] 66.9 [63.7, 69.9] 66.6 [64.0, 69.9] 66.7 [63.4, 70.2] 0.53 0.18
LS (%) −18.5 [−19.9, −17.0] −18.7 [−20.1, −17.2] −18.6 [−19.9, −17.1] −18.5 [−19.8, −16.9] −18.1 [−19.7, −16.5] 0.0001 <0.0001
Diastolic Function
TDI e′ (cm/s) 5.7 [4.8, 6.6] 5.8 [5.0, 6.9] 5.7 [4.8, 6.6] 5.6 [4.8, 6.4] 5.6 [4.7, 6.5] <0.0001 <0.0001
E/e′ ratio 11.3 [9.3, 13.7] 10.9 [9.0, 13.1] 11.3 [9.3, 13.6] 11.5 [9.5, 14.0] 11.9 [9.6, 14.8] <0.0001 <0.0001
LAVi (ml/m2) 22.9 [18.9, 27.3] 23.1 [19.3, 27.6] 22.6 [18.8, 27.1] 22.9 [19.1, 27.1] 22.9 [18.9, 27.5] 0.49 0.27
Soluble biomarkers
NT-proBNP (ng/L) 108 [58, 200] 110 [63, 195] 111 [60, 209] 101 [54, 182] 109 [53, 221] 0.087 0.63
Hs-TnT (ng/L) 10 [7, 15] 9 [7, 13] 9 [7, 14] 10 [7, 15] 12 [8, 18] <0.0001 <0.0001

Values presented are median [interquartile range]. P values are for trend across risk factor categories. Adjusted P value is adjusted for age, sex, race, and Field Center. EDV – end-diastolic volume, BSA – body surface area, LVEF – left ventricular ejection fraction, LS – LV longitudinal strain, LAVi – left atrial volume index, hs-TnT – high sensitivity troponin-T