Table 5.
The association between lifetime antipsychotic dose-years and cognitive composite score at 43 years of age in schizophrenia in linear regression analysis, models adjusted with PANSS.a
| Covariates in the model | Any antipsychotics |
Typical antipsychotics |
Atypical antipsychotics |
||||||
|---|---|---|---|---|---|---|---|---|---|
| B (SE) | Beta | Sig | B (SE) | Beta | Sig | B (SE) | Beta | Sig | |
| Gender, onset age, positive symptoms | −0.25 (0.11) | −0.32 | 0.020 | −0.20 (0.12) | −0.31 | 0.098 | −0.15 (0.09) | −0.23 | 0.087 |
| Gender, onset age, negative symptoms | −0.20 (0.10) | −0.27 | 0.047 | −0.19 (0.11) | −0.30 | 0.084 | −0.11 (0.09) | −0.16 | 0.213 |
| Gender, onset age, disorganisation symptoms | −0.08 (0.10) | −0.10 | 0.437 | −0.08 (0.10) | −0.13 | 0.445 | −0.02 (0.08) | −0.03 | 0.829 |
| Gender, onset age, hospital treatment days, educational level, positive symptoms, negative symptoms | −0.26 (0.12) | −0.34 | 0.035 | −0.32 (0.19) | −0.32 | 0.083 | −0.19 (0.15) | −0.19 | 0.227 |
B=unstandardised regression coefficient, SE=Standard Error, Beta=standardised regression coefficient, Sig=statistical significance. Statistically significant results in bold.
a
The PANSS (Positive and Negative Syndrome Scale; Kay et al., 2000) was based on a PANSS specific interview and divided into positive, negative and disorganisation symptoms based on the factor structure described by van der Gaag et al. (2006).