Table 2.
Signed Consent (N) | 28 |
Registered | 26 |
Screen Failures (N) | 6 |
Tissue not available | 5 |
Tissue not usable | 1 |
Time from consent to tissue availability, days (range) | |
All | 2.5 (0–21) |
New specimen (N=12) | 0 (0–13) |
Archival (N=8) | 4.5 (1–21) |
Time from biopsy to specimen shipment, days (range) (N=12) | 4 (2–7) |
Time from specimen shipment to report from FM, days (range) | 15.5 (12–30) |
Time from report to tumor board, days (range) | 5 (3–10) |
Recommendation within 28 days of biopsy | |
Yes | 12 (60%) |
No | 8 (40%) |
Successful NGS of metastatic biopsy (N) | 20 |
Potentially actionable mutation identified (N) | 15 |
Tumor board recommended targeted therapy as possible next treatment (N) | 13 |
Received targeted therapy as next treatment (4)* | 4 |
A patient with an AR+ tumor received bicalutamide on study, a patient with a BAP1 mutation received carboplatin/PARP inhibitor on study, a patient with a MAP2K1 amplification received trametinib off study, and a patient with an ERBB2 mutation received trastuzumab off study.