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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Allergy Clin Immunol. 2016 Jul 17;139(2):584–596.e10. doi: 10.1016/j.jaci.2016.05.047

Figure 3. Assessment of the effect of monocyte/macrophage depletion on OVA-induced ASA.

Figure 3

Mice were treated with clodronate liposomes (‘Clodronate lipo.’) or PBS liposomes (‘PBS lipo.’) 24 h before challenge. (A) OVA-induced hypothermia. (B) Levels of histamine in the plasma 20 min after challenge. (C) PAF-AH activity in the spleen 20 min after challenge. (D–I) Numbers of leukocytes in the PLF 3 days after challenge in non-sensitized mice (‘-/OVA’) or OVA-sensitized mice (‘OVA/OVA’). Data are pooled from three independent experiments for all OVA-sensitized groups (total n=8–9/group) and from one experiment for non-sensitized controls (n=4–5/group). *, ** or *** = P < 0.05, 0.01 or 0.001.