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. 2017 Jan 18;7:4. doi: 10.3389/fcimb.2017.00004

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Copyright © 2017 Thangamani, Maland, Mohammad, Pascuzzi, Avramova, Koehler, Hazbun and Seleem.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy of auranofin in C. neoformans-infected C. elegans. L4-stage worms were infected with C. neoformans and treated with auranofin, fluconazole, and flucytosine, at a concentration of 8 μg/mL. After 24 h, worms were lysed and plated onto YPD plates to determine the CFU per worm. Each dot represents average fungal load in each worm per well. The results are presented as means ± SD (n = 3). Statistical analysis was calculated using the two-tailed Student's t-test. P-value (^**P ≤ 0.01) are considered as significant.