Table 1.
MIC of auranofin and control antifungal drugs against Candida and Cryptococcus strains.
| Strains | Description | Auranofin (μg/ml) | Fluconazole (μg/ml) | Flucytosine (μg/ml) |
|---|---|---|---|---|
| C. albicans NR 29434 | Bloodstream isolate from a person with a bloodstream infection collected in Winnipeg, Manitoba, Canada, in 2000 | 8 | 4 | 0.125 |
| C. albicans ATCC 10231 | Isolated from a man with bronchomycosis | 2 | 2 | 0.25 |
| C. albicans NR 29449 | Is a vaginal isolate from a person with vaginitis collected in Ann Arbor, Michigan, USA, between 1990 and 1992 | 8 | 2 | 4 |
| C. albicans NR 29435 | Is a bloodstream isolate from a person with a bloodstream infection collected in Iowa City, Iowa, USA, in 2000 | 1 | 4 | 0.0625 |
| C. albicans NR 29448 | Is an isolate from a person with a bloodstream infection, collected in Arizona, USA. | 4 | >64 | 0.0625 |
| C. albicans NR 29437 | Is a bloodstream isolate from a person with a bloodstream infection collected in Brussels, Belgium in 2000 | 4 | 2 | 0.0625 |
| C. albicans NR 29446 | Is a bloodstream isolate from a person with a bloodstream infection collected in Utah, USA. | 16 | >64 | 0.25 |
| C. albicans NR 29453 | Is an oral isolate from an HIV+ person collected in Pretoria, South Africa | 8 | 2 | 0.0625 |
| C. albicans NR 29438 | Is a bloodstream isolate from a person with a bloodstream infection, collected in Tel-Hashomer, Israel, in 2000. | 16 | 2 | 0.0625 |
| C. albicans ATCC 26790 | Pulmonary candidiasis | 8 | 2 | 0.0625 |
| C. albicans ATCC 24433 | Nail infection | 8 | 4 | 1 |
| C. albicans ATCC 14053 | Human blood, Bethesda, MD | 8 | 4 | 0.125 |
| C. albicans ATCC 90028 | Blood, Iowa | 16 | 4 | 1 |
| C. albicans NR 29366 | Human isolate collected in China | 16 | >64 | 0.0625 |
| C. albicans NR 29367 | Human isolate collected in China. | 16 | >64 | 0.0625 |
| C. glabrata ATCC MYA-2950 | – | 8 | 4 | 0.0625 |
| C. glabrata ATCC 66032 | – | 8 | 2 | 0.0625 |
| C. tropicalis ATCC 13803 | – | 16 | 2 | 0.125 |
| C. tropicalis ATCC 1369 | – | 4 | 1 | 0.25 |
| C. parapsilosis ATCC 22019 | Case of sprue, Puerto Rico | 4 | 1 | 0.25 |
| C. neoformans NR-41291 | Obtained from human cerebrospinal fluid in China in July 2011. | 4 | 1 | 0.5 |
| C. neoformans NR-41292 | Obtained from human cerebrospinal fluid in China in February 2012. | 0.5 | 1 | 0.5 |
| C. neoformans NR-41296 | Obtained from human cerebrospinal fluid in China in February 2012. | 1 | 2 | 0.5 |
| C. neoformans NR-41295 | Obtained from human cerebrospinal fluid in China in February 2012. | 4 | 2 | 0.5 |
| C. neoformans NR-41294 | Obtained from human cerebrospinal fluid in China in June 2011. | 0.5 | 4 | 2 |
| C. neoformans NR-41297 | Obtained from human cerebrospinal fluid in China in February 2012. | 1 | 8 | 4 |
| C. neoformans NR-41298 | Obtained from human cerebrospinal fluid in China in February 2012. | 1 | 4 | 2 |
| C. neoformans NR-41299 | Obtained from human cerebrospinal fluid in China in August 2009. | 4 | 4 | 2 |
| C. neoformans NR-41291 | Obtained from human cerebrospinal fluid in China in July 2011. | 1 | 4 | 1 |
| Cryptococcus gattii—CBS1930 | Isolated from a goat in Aruba prior to the outbreak in Vancouver, British Columbia, Canada. | 0.5 | 2 | 2 |
| Cryptococcus gattii—R265 | Isolated from a human on Vancouver Island, Canada during the outbreak that began in the late 1990's | 1 | 1 | 1 |
| Cryptococcus gattii—Alg40 | Progeny of a genotypic cross between C. gattii strains R265 and CBS1930. | 0.5 | 2 | 0.5 |
| Cryptococcus gattii—Alg75 | Progeny of a genotypic cross between C. gattii strains R265 and Alg40. | 8 | 8 | 8 |
| Cryptococcus gattii—Alg81 | Progeny of a genotypic cross between C. gattii strains R265 and Alg75. | 4 | 8 | 4 |
| Cryptococcus gattii—Alg99 | Progeny of a genotypic cross between C. gattii strains R265 and Alg81. | 4 | 8 | 4 |
| Cryptococcus gattii—Alg114 | Progeny of a genotypic cross between C. gattii strains R265 and Alg99. | 8 | 8 | 4 |
| Cryptococcus gattii—Alg115 | Progeny of a genotypic cross between C. gattii strains R265 and Alg114. | 8 | 8 | 4 |
| Cryptococcus gattii—Alg127 | Progeny of a genotypic cross between C. gattii strains R265 and Alg115. | 4 | 4 | 4 |