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. 2017 Jan 18;10:590. doi: 10.3389/fnins.2016.00590

Table 5.

LD₅₀ (dose lethal to 50% of the test sample) information for selected OPs.

OPs and LD₅₀s
OP	Mouse Oral LD₅₀ (mg/kg)	Mouse Dermal LD₅₀ (mg/kg)	Rat Oral LD₅₀ (mg/kg)	Rat Dermal LD₅₀ mg/kg	Toxicity in Humans
Acephate	361^A		1030–1447^A		Moderate^B
Azinphos-methyl	8–20^C	65^C	4^C	88–220^C	High^B
Chlorpyrifos	60^D	200^D	96–270^D	>2000^E	Moderate^B
Diazinon	80–135^F		300–1250^G		Moderate^B
Dichlorvos	61–175^C^,^H	206^C	50 < 500^C^,^H	70.4–250^C^,^H	Moderate^B
Dimethoate	160^C		30–330^I	100–2000^C^,^I	Moderate ^B
Disulfoton			2–12^J	3.6–15.9^J	High^B
Ethoprop			61.5^K		Moderate^B
Fenamiphos	22.7^H		2–24.8^H	72–154^H	High^B
Malathion	400–4000^C		1000–5500^C	>4000^C	Low^B
Methamidophos			16–21^G	50^G	High^B
Methidathion	18–25^C^,^G		25–54^C^,^G	85–94^C^,^G	Moderate^B
Methyl Parathion	14.5–19.5^C^,^G	1200^C^,^G	6–50^C^,^G	67^C^,^G	High^B
Naled	330–375^D		91–430^D	800^D	Moderate^B
Oxydemeton-methyl			50^L	85^L	Moderate^B
Phorate	2.25–6.59^C		1.1–4^C	2.5–6.2^C^,^G	High^B
Phosmet	23.1–50.1^M		113–316^M		Moderate^B
Profenofos	298^N		358–1178^N	300–2000^N	Moderate^B

^A

Worthing et al., 1987.

^B

Roberts and Reigart, 2013.

^C

Gallo and Lawryk, 1991.

^D

Meister, 1992.

^E

Racke, 1992.

^F

World Health Organization, 2009.

^G

Kidd and James, 1991.

^H

U.S. Public Health Service, 2016.

^I

Cheminova Agro A/S, 1991.

^J

U.S. Environmental Protection Agency, 1984.

^K

Powers, 1965.

^L

Sax, 1984.

^M

Food and Agriculture Organization of the United Nations, 1978.

^N

Food and Agriculture Organization of the United Nations, 2011.