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. 2017 Jan 18;10:621. doi: 10.3389/fnins.2016.00621

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Copyright © 2017 Salvi, Sun, Ding, Chen, Lobarinas, Wang, Radziwon and Auerbach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic illustrating threshold in quiet before and after a moderate dose of carboplatin. (B) Schematic representing the IHC and OHC loss after a moderate dose of carboplatin that induces a 60–70% IHC with little or no loss of OHC. (C) Schematic showing the threshold in 50 dB SPL broadband noise before and after moderate dose of carboplatin. (D) Schematic illustrating the thresholds measured in narrowband noise (100 Hz bandwidth) centered at 4 kHz before and after a moderate dose of carboplatin. Carboplatin-induced threshold elevations above 4 kHz reflect the upward spread of masking and those below 4 kHz reflect remote masking. Data schematized from Lobarinas et al. (2016).