Fig. 3.

Chemo-irradiation leads to increased plasma levels of NK cell-activating cytokines. Plasma levels of IL-2, IL-15, IL-18, and IL-21 were measured at different time points after treatment of 4T1 tumor-bearing B6CBAF1 mice with CY+TBI, as indicated. Per time point the median plasma level, and SEM are shown of five mice per time point. The increases in plasma levels were highly statistically significant (p < 0.001) compared to non-chemo-irradiated mice for all four measured cytokines at the first three time points and statistically significant (p < 0.01) for IL-15, IL-18, and IL-21 at the two last time points