Fig. 5.

NK cells mediate i.v. injected 4T1 breast cancer elimination in MHC-mismatched hosts. PFS curves of two separate experiments where B6CBAF1 mice were injected with 4T1 breast cancer cells i.v. at day 0 followed by either no further treatment (n = 16) or AsialoGM1 depletion [a n = 16, anti-AGM1 applied (arrows) during the first 2 weeks] or NK1.1 depletion [b n = 15, anti-NK1.1 applied (arrows) during whole experiment]. All events were breast cancer-related deaths. Statistically significant differences or trends of PFS compared to the “no further treatment” groups are indicated by ^¶ p < 0.001 and ^• p = 0.02