Table 2.

Alloreactive NK cells prevent pulmonary metastasis of i.v. injected 4T1 breast cancer cells in the fully MHC-mismatched host

Exp. no.	Treatment group (all had i.v. 4T1 tumor injection)	Recipient mouse strain	Mortality from pulmonary metastases	p value
5.	No further treatment	CB6F1	10/10	Reference
	No further treatment	B6CBAF1	0/11	<0.01
6.	No further treatment	B6CBAF1	2/16	Reference
	Anti-AsialoGM1 NK cell depletion at days 0, 5, and 10	B6CBAF1	8/16	0.06
7.	No further treatment	B6CBAF1	3/16	Reference
	Anti-NK1.1 NK cell depletion from day 0 until the end of the experiment	B6CBAF1	12/15	<0.01

Pulmonary metastases were evident by development of severe pulmonary distress requiring sacrifice. Follow-up time was 130 days after 4T1 i.v. injection in exp. nos. 5 and 6, and 100 days in exp. no. 7