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. 2016 Sep 1;74(3):399–408. doi: 10.1007/s00018-016-2350-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Exocytosis of cytotoxic granules. Secretion of cytotoxic granules (CGs) is a sequential process requiring exocytosis of recycling endosomes (RE) as an initial step (1). Thereby REs deliver components of the exocytic machinery for CGs such as the SNARE-associated protein Munc13-4 and the SNARE protein syntaxin11 (STX11) (2). Together with further, currently unknown SNARE proteins, those components serve as a docking platform for cytotoxic granules and initiate CG fusion through Munc13-4-catalyzed SNARE complex formation (3)