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. 2017 Jan 8;174(3):267–280. doi: 10.1111/bph.13682

Figure 8.

Figure 8

Cortistatin levels in myocardium and serum positively correlate with EAM severity. Mice with MyHC614–629‐induced EAM were treated i.p. with PBS (EAM) or cortistatin (EAM + CST) three times per week for 2 weeks. At day 21, heart RNA and sera were isolated and subjected to quantitative real‐time PCR to determine cortistatin gene expression and to elisa to determine blood levels of cortistatin and BNP. (A) Results are expressed as cortistatin gene expression relative to GAPDH. n = 5 mice per group. *P < 0.05. (B) Cortistatin levels in sera. n = 16 mice per group. *P < 0.05. (C) Correlation between cortistatin gene expression in the heart and EAM severity (measured as heart‐to‐body weight ratios). (D) Correlation between cortistatin and BNP levels in serum of mice with EAM. Each symbol in (C and D) represents individual mice; r 2 corresponds to the value of correlation obtained with the linear regression analysis.