Table 1. Comparison of biochemical parameters and antioxidant status of the serum in rats after 1 and 4 weeks of treatment with JRSME.

	One week		Four weeks
	Control group (n=6)	Treated group (n=6)	Control group (n=6)	Treated group (n=6)
AST (unit/L)	166.5 ± 30.3	141.1 ± 19.2	162.5 ± 21.9	177.5 ± 21.7b*
ALT (unit/L)	77.2 ± 15.8	65.5 ± 17.3	102.8 ± 10.9b*	122.7 ± 22.8b**
SOD (unit/ml)	242.9 ± 18.9	247.5 ± 13.5	253.9 ± 13.7	255.8 ± 9.7
GPx (unit/L)	10258.7 ± 695.7	11156.4 ± 679.9	10569.3 ± 915.7	11410.8 ± 536.4
PON-1 (µmol/min/ml)	108.4 ± 8.6	101.1 ± 11.2	101.4 ± 9.1	110.4 ± 8.0
MDA (nmol/ml)	2.0 ± 0.4	1.9 ± 0.4	1.6 ± 0.3	3.1 ± 0.7a**b***
Urea (mg/dl)	48.7 ± 7.1	53.3 ± 11.7	46.3 ± 7.2	36.2 ± 4.4a*b**
Cr (mg/dl)	0.5 ± 0.1	0.5 ± 0.2	0.5 ± 0.1	0.4 ± 0.2

Data are expressed as mean ± SD for six animals in each group. ^a: compared with the control group; ^b: Week 1 vs. Week 4; ^*p<0.05, ^**p<0.01, ^***p<0.001. JRSME, Juglans regia septum of methanol extract; AST, aspartate transaminase; ALT, alanine transaminase; SOD, superoxide dismutase ; GPx, glutathione peroxidase; PON-1, paraoxonase 1; MDA, malondialdehyde; Cr, creatinine.