Table 1. Effect (mean±SD of ΔV in mL, % of reduction) of TE and dexamethasone on paw edema induced by Bjssu venom.
| Groups | Dose (mg/kg) | Mean and Standard deviation of ΔV (mL) and percent of reduction of paw edema (induced by 0.5 μg of Bjssu) | |||||
| 30 min | 1 h | 2 h | 3 h | 4 h | 5 h | ||
| Control | --- | 0.13 ± 0.03 | 0.12 ± 0.03 | 0.10 ± 0.02 | 0.09 ± 0.01 | 0.08 ± 0.02 | 0.08 ± 0.02 |
| Dexamethasone | 2 mg/kg (i.p.) | 0.12 ± 0.04 (10.0%) | 0.07 ± 0.03* (39.5%) |
0.05 ± 0.02* (51%) |
0.04 ± 0.02* (57%) |
0.03 ± 0.02* (60%) |
0.03 ± 0.02* (66%) |
| TE | 250 mg/kg | 0.12 ± 0.04 (13.7%) |
0.06 ± 0.03* (53.5%) |
0.05 ± 0.03* (45.6%) |
0.05 ± 0.02* (44.6%) |
0.04 ± 0.01* (52%) |
0.04 ± 0.02* (54%) |
| TE | 500 mg/kg | 0.13 ± 0.03 (2.5%) |
0.07 ± 0.02* (35%) |
0.07 ± 0.02* (34%) |
0.06 ± 0.01* (39.5%) |
0.05 ± 0.02* (40%) |
0.05 ± 0.02* (44%) |
| TE | 1000 mg/kg | 0.12 ± 0.02 (12.5%) |
0.05 ± 0.03* (53.4%) |
0.06 ± 0.01* (42%) |
0.03 ± 0.02* (66%) |
0.04 ± 0.03* (52%) |
0.03 ± 0.03* (66%) |
Mean and Standard deviation of ΔV represent the mean difference of paw volume between the basal measure and measures at each time point (30 min, 1, 2, 3, 4 and 5 h), n = 5. Percent of reduction of paw edema (previously induced by 0.5 μg of Bjssu) was calculated considering the paw volume for each group in comparison to the control group at each time interval. The symbol * represent significant differences when comparing each group to control (p<0.05; ANOVA - Dunnett’s test).