Table 2. Primary information for hsa-mir-499 rs3746444 T/C, IRAK1 rs3027898 C/A and RANKL rs7984870 C/G polymorphisms.
Genotyped SNPs | Chromosomes | Location | Regulome DB scorea | TFBSb | Splicing (ESE or ESS) c | MAFd for Chinese in database | MAF in our controls (n = 480) | p value for HWEe test in our controls | % Genotyping value |
hsa-mir-499 rs3746444 T/C | 20 | Intron | 5 | Y | Y | 0.167 | 0.152 | < 0.05 | 96.7 |
IRAK1 rs3027898 C/A | X | 3′ near gene | 4 | — | — | 0.165 | 0.181 | < 0.05 | 99.2 |
RANKL rs7984870 C/G | 13 | Intron | No data | Y | — | 0.522 | 0.493 | 0.647 | 96.8 |
a http://www.regulomedb.org/; b TFBS, Transcription Factor Binding Site; c http://snpinfo.niehs.nih.gov/snpinfo/snpfunc.htm; d MAF, minor allele frequency; e HWE, Hardy-Weinberg equilibrium.