Table 3. Logistic regression analysis of associations between hsa-mir-499 rs3746444 T/C, IRAK1 rs3027898 C/A and RANKL rs7984870 C/G polymorphisms and risk of CAD.

Genotype	CAD cases (n = 435)		Controls (n = 480)		OR (95% CI)	p	Adjusted ORa (95% CI)	p
	n	%	n	%
hsa-mir-499 rs3746444 T/C
TT	264	62.7	342	73.7	1	—	1	—
TC	110	26.1	103	22.2	1.38 (1.01-1.89)	0.04	1.41 (1.02-1.94)	0.04
CC	47	11.2	19	4.1	3.20 (1.84-5.59)	< 0.001	3.14 (1.77-5.56)	< 0.001
TC+CC	157	37.3	122	26.3	1.67 (1.25-2.22)	< 0.001	1.68 (1.25-2.26)	< 0.001
TT+TC	374	88.8	445	95.9	1	—	1	—
CC	47	11.2	19	4.1	2.94 (1.70-5.10)	< 0.001	2.87 (1.63-5.04)	< 0.001
C allele	204	24.2	141	15.2
IRAK1 rs3027898 C/A
CC	328	75.9	348	73.1	1	—	1	—
CA	59	13.7	84	17.6	0.75 (0.52-1.07)	0.12	0.76 (0.52-1.11)	0.15
AA	45	10.4	44	9.2	1.09 (0.70-1.69)	0.72	1.01 (0.64-1.59)	0.97
CA+AA	104	24.1	128	26.9	0.86 (0.64-1.16)	0.33	0.85 (0.62-1.16)	0.30
CC+CA	387	89.6	432	90.8	1	—	1	—
AA	45	10.4	44	9.2	1.14 (0.74-1.77)	0.55	1.06 (0.68-1.66)	0.80
A allele	149	17.2	172	18.1
RANKL rs7984870 C/G
CC	95	22.7	123	26.3	1	—	1	—
CG	209	50	229	48.9	1.18 (0.85-1.64)	0.32	1.15 (0.82-1.61)	0.43
GG	114	27.3	116	24.8	1.27 (0.88-1.85)	0.21	1.16 (0.79-1.71)	0.44
CG+GG	323	77.3	345	73.7	1.21 (0.89-1.65)	0.22	1.15 (0.84-1.59)	0.38
CC+CG	304	72.7	352	75.2	1	—	1	—
GG	114	27.3	116	24.8	1.14 (0.84-1.54)	0.40	1.06 (0.78-1.45)	0.71
G allele	437	52.3	461	49.3

^a Adjusted for age, sex, smoking, drinking, hypertension, diabetes mellitus, family history of CAD; Bold values are statistically significant (p < 0.05). CI, confidence interval; OR, odds ratio.