Table 5.
DNA methylation results, presented as relative methylation (mean ± SD) compared to CD or in the HFD groups, respectively, for every CpG (stars indicate significance: ∗ p value ≤ 0.05, ∗∗ p value ≤ 0.01).
| Mean ± SD in % | CD + EGCG compared to CD | HFD compared to CD | HFD + EGCG compared to HFD |
|---|---|---|---|
| Dnmt1 liver | |||
| CpG1 | 1.71 ± 0.32∗ | 0.93 ± 0.25 | 1.62 ± 0.33∗ |
| CpG2 | 1.14 ± 0.21 | 0.81 ± 0.12 | 1.10 ± 0.39 |
| CpG3 | 1.37 ± 0.14∗∗ | 1.48 ± 0.73 | 1.18 ± 0.19 |
| CpG4 | 1.19 ± 0.40 | 0.88 ± 0.48 | 1.39 ± 0.21 |
| Dnmt1 colon | |||
| CpG1 | 1.07 ± 0.16 | 1.17 ± 0.24 | 0.89 ± 0.06 |
| CpG2 | 1.15 ± 0.30 | 1.12 ± 0.14 | 1.19 ± 0.14∗ |
| CpG3 | 0.98 ± 0.27 | 1.01 ± 0.19 | 1.23 ± 0.42 |
| CpG4 | 1.28 ± 0.09∗ | 1.17 ± 0.12 | 0.98 ± 0.13 |
| MLH1 colon | |||
| CpG1 | 0.38 ± 0.20∗ | 1.08 ± 0.46 | 0.98 ± 0.48 |
| CpG2 | 0.66 ± 0.39 | 0.40 ± 0.03∗ | 0.65 ± 0.13∗ |
| CpG3 | 1.04 ± 0.27 | 1.36 ± 0.44 | 0.87 ± 0.31 |
| CpG4 | 0.62 ± 0.11∗ | 2.13 ± 0.12∗ | 0.76 ± 0.42 |
| CpG5 | 1.75 ± 0.10∗ | 1.24 ± 0.09∗ | 0.55 ± 0.11∗ |
| CpG6 | 0.37 ± 0.14∗ | 1.53 ± 0.37 | 0.68 ± 0.70∗ |
| MLH1 liver | |||
| CpG1 | 0.56 ± 0.02∗∗ | 0.43 ± 0.03 | 0.98 ± 0.21 |
| CpG2 | 1.65 ± 0.61 | 1.27 ± 0.37∗∗ | 1.80 ± 0.42∗∗ |
| CpG3 | 1.11 ± 0.09 | 0.75 ± 0.13 | 1.16 ± 0.10 |
| CpG4 | 2.73 ± 1.06∗∗ | 1.73 ± 0.08∗∗ | 1.13 ± 0.15 |
| CpG5 | 1.20 ± 0.08∗∗ | 1.12 ± 0.26∗∗ | 0.86 ± 0.05∗∗ |
| CpG6 | 1.20 ± 0.10∗ | 1.60 ± 0.47 | 0.68 ± 0.16∗∗ |