Table 2.

Characteristics of clinical study subjects carrying the N363S glucocorticoid receptor single nucleotide polymorphism and noncarrier control

Demographic	Control	N363S	P Value
Race: Caucasian, non-Hispanic, n	36	18
Age, yr	50.0 ± 2.0	44.7 ± 3.3	0.18
Male, n	14	6
Female, n	22	12
BMI	28.6 ± 1.2	30.5 ± 1.8	0.40
Waist circumference, cm	95.4 ± 2.4	100.0 ± 4.8	0.40
Systolic blood pressure	131.4 ± 3.2	136.2 ± 4.3	0.38
Diastolic blood pressure	75.8 ± 1.7	74.0 ± 2.1	0.51
Laboratory (normal range)
CRP (<3.0 mg/l)	2.6 ± 0.7	3.2 ± 0.9	0.59
Cholesterol (<200 mg/dl)	187.3 ± 7.1	205.3 ± 10.6	0.17
HDL (40–59 mg/dl)	51.0 ± 2.5	54.2 ± 3.7	0.47
LDL (100–129 mg/dl)	110.3 ± 5.6	127.2 ± 7.8	0.09
Triglycerides (<150 mg/dl)	130.8 ± 9.8	119.1 ± 14.3	0.51
Creatinine (0.56–1.16 mg/dl)	0.79 ± 0.02	0.76 ± 0.04	0.54
Glucose (70–115 mg/dl)	88.7 ± 1.4	87.6 ± 2.1	0.66
Insulin (6–27 mcU/ml)	7.2 ± 1.0	18.0 ± 5.7	0.08
Cortisol (5–25 mcg/dl)	11.6 ± 0.7	11.2 ± 1.2	0.77
DST cortisol (n 32,15)	7.6 ± 1.0	6.9 ± 1.1	0.61

Means ± SE are shown.

BMI, body mass index; CRP, C-reative protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; DST, dexamethasone suppression test.

Any subjects taking the medications metformin, rosiglitazone, or glimepiride for any condition or identified with type 2 diabetes during physical examination were excluded from the data analysis. P value, unpaired t-test with Welch's correction.