Fig. 6.

Metabolic gene expression in the liver of Ctrp1 KO male mice fed a LFD. A: expression of cholesterol and bile acid metabolism genes in WT (n = 8) and KO (n = 8) mouse livers. B: expression of genes involved in TG synthesis in WT (n = 9) and KO (n = 9) mouse livers. D–G: expression of genes involved in lipid uptake and de novo fatty acid synthesis (C), fat oxidation (D), TG lipolysis (E), and inflammation (F) in WT (n = 8–9) and KO (n = 8–9) mouse livers. Expression levels were normalized to β-actin. All data are expressed as means ± SE. *P < 0.05. Abca1, ATP-binding cassette subfamily A member 1; Abcg, ATP-binding cassette subfamily G; Acc, acetyl CoA carboxylase; Acox1, acyl CoA oxidase 1; Agpat, 1-acylglycerol-3-phosphate O-acyltransferase; Apob, apolipoprotein B; Apoc2, apolipoprotein C2; Apoe, apolipoprotein E; Chrebp, carbohydrate-responsive element-binding protein; Cpt, carnitine palmitoyltransferase; Cyp, cytochrome P-450; Dgat, diacylglycerol O-acyltransferase; Fabp, fatty acid-binding protein; Fasn, fatty acid synthase; Fxr, farnesoid X receptor; Gpat, glycerol-3-phosphate acyltransferase; Hmgcr, HMG-CoA reductase; Idol, inducible degrader of the LDL receptor; Lcad, long-chain acyl-CoA dehydrogenase; Lcat, lecithin-cholesterol acyltransferase; LDLr, LDLreceptor; Lipc, lipase, hepatic; Lpl, lipoprotein lipase; Lrp1, LDL receptor-related protein 1; Lxr, liver X receptor; Mcad, medium-chain CoA dehydrogenase; Mlycd, malonyl-CoA decarboxylase; Pcsk9, proprotein convertase subtilisin/kexin type 9; Scd1, stearoyl-CoA desaturase-1; Sort1, sortilin; Sqle, squalene epoxidase; Srebp1c, sterol regulatory element-binding protein 1c; Vldlr, VLDL receptor.