Table 2.
Plasma AA concentrations in piglets infused with leucine at the end of 8-h endotoxemic pancreatic-substrate clamps
| AA | Con | Con+L | LPS | LPS+L |
|---|---|---|---|---|
| EAAs | ||||
| Arginine | 89.7 ± 10.8a | 113 ± 10.7b | 86.6 ± 9.90a | 98.4 ± 10.3a,b |
| Histidine | 55.3 ± 12.7a,b | 45.7 ± 12.5a | 68.8 ± 11.1a,b | 81.1 ± 11.9b |
| Isoleucine | 191 ± 24.4 | 193 ± 24.1 | 200 ± 22.0 | 216 ± 23.2 |
| Leucine | 136 ± 59.9a | 335 ± 53.6b | 133 ± 45.3a | 290 ± 45.3b |
| Lysine | 192 ± 24.0 | 186 ± 23.7 | 153 ± 20.8 | 206 ± 22.2 |
| Methionine | 80.8 ± 14.2 | 76.8 ± 14.0 | 61.1 ± 12.8 | 78.3 ± 13.5 |
| Threonine | 181 ± 25.7 | 213 ± 25.3 | 222 ± 22.6 | 238 ± 24.1 |
| Tryptophan | 27.8 ± 4.50a | 32.6 ± 4.40a,b | 34.3 ± 4.00a,b | 41.8 ± 4.20b |
| Valine | 333 ± 46.4 | 312 ± 45.7 | 316 ± 41.9 | 393 ± 44.1 |
| NEAAs | ||||
| Alanine | 323 ± 82.6 | 362 ± 81.3 | 403 ± 72.8 | 446 ± 77.4 |
| Asparagine | 68.9 ± 10.4 | 78.2 ± 10.2 | 80.4 ± 9.50 | 80.3 ± 9.90 |
| Aspartic acid | 10.0 ± 1.90 | 10.7 ± 1.90 | 9.70 ± 1.60 | 14.5 ± 1.70 |
| Glutamine | 342 ± 52.8a | 406 ± 52.3a,b | 422 ± 45.7a,b | 513 ± 48.9b |
| Glycine | 1,030 ± 116 | 1,090 ± 114 | 1,034 ± 101 | 1,280 ± 108 |
| Ornithine | 77.4 ± 10.4 | 77.9 ± 10.2 | 73.2 ± 9.10 | 83.3 ± 9.70 |
| Proline | 153 ± 21.0 | 162 ± 21.1 | 175 ± 18.3 | 202 ± 19.6 |
| Serine | 134 ± 19.8 | 167 ± 19.8 | 141 ± 17.2 | 184 ± 18.4 |
| Taurine | 77.4 ± 17.7a | 78.6 ± 17.4a | 131 ± 15.4b | 142 ± 16.5b |
| Tyrosine | 149 ± 19.4 | 141 ± 19.1 | 161 ± 17.0 | 177 ± 18.1 |
| Glutamate | 51.0 ± 15.0a | 57.4 ± 15.0a,b | 49.6 ± 13.2a | 82.3 ± 13.7b |
| Citrulline | 92.4 ± 11.8 | 116 ± 11.7 | 103 ± 11.0 | 111 ± 11.4 |
| EAAs | 1,326 ± 156 | 1,440 ± 154 | 1,300 ± 139 | 1,601 ± 148 |
| NEAAs | 2,440 ± 261a | 2,730 ± 261a,b | 2,770 ± 226a,b | 3,330 ± 242b |
| Branched-chain AAs | 708 ± 102a,b | 780 ± 101a,b | 671 ± 93.6a | 892 ± 101b |
| Total AAs | 3,740 ± 380a | 4,160 ± 380a,b | 4,033 ± 329a,b | 4,880 ± 351b |
Values are means ± SE; n = 6–8 at time = 480 min of infusion. AA are shown in mmol/ml. Phenylalanine was used as a tracer to determine protein synthesis rates; its value was elevated at time = 480 min. Consequently, this AA was excluded from total AA and essential AA (EAA) values.
NEAAs, nonessential AAs.
Means without a common letter differed (P ≤ 0.05).