Figure 3.

Different glycosylation profiles of wild-type TREM2 and the R47H variant. (A) Extracted compound chromatograms (ECCs) of N-glycans found in wild-type TREM2 (top) and the R47H variant (bottom). Colors denote different glycan classes. (B) Bar graph of relative abundances and standard errors associated with complex, hybrid, and high mannose type N-glycans (to indicate the statistically significant differences between wild-type TREM2 and the R47H variant, the t-test p-values are shown.) (C) Relative abundances and standard errors associated with the undecorated complex type glycans. (D) Relative abundances and standard errors associated with the sialylated and fucosylated complex type glycans.