Figure 5.

Immunohistochemistry of tyrosine hydroxylase (TH) in the substantia nigra pars compacta (SNpc) and striatum from WT and LRRK2^R1441G mutant mice after 50-week oral rotenone administration. Scale = 150 μm (a) and 200 μm (b). There was no significant difference in TH-positive cell numbers in SNpc and striatal TH staining density between WT and mutant mice rotenone treatment (Student’s unpaired t-test). Data represents mean ± standard error of mean (SEM) from three independent experiments (N = 3).