Figure 6. Protein expression levels of mitochondrial respiratory Complex-I subunit (NDUFS4), TH and CoxIV in mouse striatum after 50-week oral rotenone administration.

Mitochondrial NDUFS4 levels were specifically decreased in mutant mice after rotenone treatment, which was not seen in those similarly treated WT mice. There were no significant changes in both TH and CoxIV levels between WT and mutant mice after rotenone treatment. Data represents mean ± standard error of mean (SEM) from at least four mice per group; Statistical significance between groups was analyzed using Student’s unpaired t-test, **P < 0.01.